{"product_id":"synocrom-1-x-2-ml","title":"Synocrom 1x 2.0 ml","description":"\u003cdiv class=\"page\" title=\"Page 1\"\u003e\n\u003cdiv class=\"section\"\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cdiv class=\"column\"\u003e\n\u003cp\u003eInstructions for use of \u003ca href=\"https:\/\/stakonmed.de\/collections\/synocrom\" title=\"Synocrom | Joint Injections | StakonMed\"\u003eSynocrom\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003c\/span\u003e\u003cspan\u003e1. Purpose and Indications\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis product is a medical device intended for use in humans and is injected into synovial joints (knee, hip, ankle, and shoulder) to restore the natural viscoelastic properties of the synovial fluid (viscosupplementation). It is indicated for the treatment of pain and restricted mobility due to degenerative or traumatic changes in synovial joints (osteoarthritis).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e2. Description\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe product consists of a sterile, isotonic, viscoelastic solution for intra-articular use and is supplied in a prefilled syringe. Each prefilled syringe contains 2 ml of the viscoelastic solution. 1 ml of the product contains: 10 mg (1%) sodium hyaluronate as well as sodium chloride, sodium monohydrogen phosphate, citric acid, and water for injection purposes. The product is delivered sterile and is intended for single use only. The product is steam sterilized in its blister packaging (sterile barrier). No ingredients or raw materials of animal origin are used in the manufacture of the product. The product contains no medicinal active substances.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e3. Method of Administration and Dosage\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eRemove the prefilled syringe from the sterile container, carefully unscrew the rubber cap from the Luer-Lock connector, attach a suitable needle, and secure it with a slight twist. Hold the syringe during administration as shown in Figure 1. Depending on the size of the joint, up to 2 ml can be administered intra-articularly. For knee application, 3 to 5 injections of the product at weekly intervals are recommended. For hip, ankle, and shoulder, 1 to 5 injections may be required; clinical experience and patient improvement should guide the number of applications. Multiple joints can be treated simultaneously, and treatment cycles can be repeated. To avoid intra-articular infections, the injection must be performed under strict aseptic conditions. It is recommended to apply an ice pack to the treated joint for 5–10 minutes after administration to prevent pain and swelling.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e4. Properties and Mode of Action\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn patients with degenerative joint disease (osteoarthritis), the viscoelasticity of the synovial fluid is significantly impaired. This leads to mechanical stress on the joint and degradation of the articular cartilage, which in turn causes restricted joint mobility and pain. The lubricating and shock-absorbing properties of this product contribute to pain relief and improved joint mobility. After a treatment cycle of three to five intra-articular injections, this effect can last for several months.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e5. Contraindications and Possible Interactions\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe product must not be used in patients with known hypersensitivity to any of the ingredients. Since this product is injected intra-articularly, patients with bacterial arthritis should be excluded from treatment to avoid possible complications. Currently, there is no information on undesirable interactions with other intra-articularly administered therapies.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e6. Side Effects and Adverse Events\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eLocal symptoms in the treated joint (pain, warmth, redness, and swelling) may occur after administration. With comparable products, the following adverse events have been reported: mild to moderate joint pain, rarely rash, aseptic joint effusions, pruritus, and muscle cramps. In very rare cases, the following adverse events have also been observed: allergic reactions, anaphylactic shock, hemarthrosis, phlebitis, pseudosepsis, severe acute inflammatory reactions (SAIR), nasopharyngitis, joint stiffness, tendinitis, bursitis, fever, and myalgia.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e7. Warnings\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe product should only be administered by physicians trained in intra-articular injections. They should also be familiar with all immunological and other risks associated with the use of biological materials. The product has not been studied in pregnant women or in children\/adolescents under 18 years of age. Keep the product out of sight and reach of children. The product is for single use only; the syringe must not be resterilized after use. Reuse of the product carries a potential infection risk for patients and users. Do not use if the sterile barrier (blister pack) is opened and\/or damaged. Do not use any syringe whose protective cap in the sterile packaging (blister pack) is opened or displaced. Do not use after the expiration date. Patients should be advised to rest the treated joints for 24 hours after each injection (but not immobilize completely) to avoid overuse.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e8. Storage\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eStore the product at room temperature (2–25 °C) and protect from frost and moisture. Package sizes: 1, 3, 5, or 50 prefilled syringes\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e9. Information Date\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e05\/2015\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"BAUSCH \u0026 LOMB GmbH Surgical","offers":[{"title":"Default Title","offer_id":47355881095508,"sku":"143","price":19.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0786\/8756\/8212\/files\/synocrom-bausch-lomb-gmbh-surgical-gelenkspritzen-stakonmed-309145.jpg?v=1772216007","url":"https:\/\/stakonmed.at\/en\/products\/synocrom-1-x-2-ml","provider":"StakonMed","version":"1.0","type":"link"}